Fig. 7.
Fig. 7. Effect of functional blockade of endothelial adhesion molecules on VT-1–induced thrombus formation on HMEC-1. / Cells pretreated with VT-1 (10 pM, 24 hours) were incubated with the following adhesion blocking antibodies: anti-β3-integrin subunit (7E3 Fab 20 μg/mL for 20 minutes), anti-αvβ3 (LM609 10 μg/mL for 10 minutes), anti-P-selectin (50 μg/mL for 20 minutes), and anti-PECAM-1 (25 μg/mL for 10 minutes) before blood perfusion at 60 dynes/cm2. Data are expressed as mean ± SE (n = 6 experiments). °P < .01 versus untreated cells. *P < .05, **P < .01 versus VT-1.

Effect of functional blockade of endothelial adhesion molecules on VT-1–induced thrombus formation on HMEC-1.

Cells pretreated with VT-1 (10 pM, 24 hours) were incubated with the following adhesion blocking antibodies: anti-β3-integrin subunit (7E3 Fab 20 μg/mL for 20 minutes), anti-αvβ3 (LM609 10 μg/mL for 10 minutes), anti-P-selectin (50 μg/mL for 20 minutes), and anti-PECAM-1 (25 μg/mL for 10 minutes) before blood perfusion at 60 dynes/cm2. Data are expressed as mean ± SE (n = 6 experiments). °P < .01 versus untreated cells. *P < .05, **P < .01 versus VT-1.

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