Apoptotic pathways disrupted in MCL as detected by microarray analysis and confirmed by real-time PCR.

Expression of several genes acting in concert to regulate the balance between proliferation and programmed cell death are altered in MCL as compared to nonmalignant HLs. The down-regulation of FADD causes a blockade of the FAS-FADD apoptotic pathway leading to secondary changes in expression of proapoptotic genes. In addition, PDCD1 and RAIDD, which can directly induce apoptosis, are markedly down-regulated in MCL.