Neutrophil influx into the peritoneal cavity during thioglycolate-induced peritonitis.
Thioglycolate was injected into the peritoneal cavity of 4 to 8 wild-type mice (diamonds) or triple-null mice (squares). Values represent the mean ± SD number of neutrophils recovered from peritoneal lavage at the indicated times. The differences between the triple-selectin–null mice and the wild-type mice were significant (P < .001) at all times studied. Solid circles represent the number of neutrophils collected after intravenous administration of the α4-integrin–blocking mAb PS/2 to triple-null mice 1 hour before and 6 hours after thioglycolate injection. Although we hypothesized that this blocking antibody might reduce neutrophil emigration into the peritoneal cavity, we observed no effect in this model.
