Sequences within GPIbβ compared with other calmodulin-recognition sequences.

(A) Sequence alignment of a cytoplasmic sequence of GPIbβ, R149–L167,17 with calmodulin-binding sequences in a model calmodulin-binding control peptide CBCP,23,26L-selectin,27 and m7A.28 Identical amino acids or conserved substitutions are boxed. (B) Helical wheel representation of the GPIbβ sequence (R149–L167) compared with the amphipathic α-helical peptide CBCP.