Updating of the initial guess of dose-toxicity relationship after enrollment of 47 patients.

Data available on the 47 treated patients were modeled using CRM. The results are presented as the initial guesses (▪) of probability of toxicity at each dose level, updated (▴) after enrollment of 47 patients, using either 23 Gy (A) or 25 Gy (B) as the initial candidate for MTD. Modeling used a 1-parameter logistic model with the scale parameter fixed at 3 and a unit exponential prior for the shape parameter.