Generation of AML-like disease by human CD34^low/− SP cells in the NOD/SCID mouse.

Leukemic blasts staining positively for human CD45 were found infiltrating the murine host spleen (panel A, 60 ×) and the bone marrow (panel B, 100 ×). FISH with a centromeric probe for chromosome 7 (D7Z1) showed monosomic blasts infiltrating the bone marrow of this mouse (panel C, 100 ×).