Proposed model of major hematolymphoid maturation pathways from HSCs in the fetal liver.

We propose that FL HSCs give rise to at least FL CLPs, which can form all cells of the lymphoid lineages,17 and FL CMPs, which can differentiate into either FL GMPs or FL MEPs that then form the cells of the granulocyte–monocyte or megakaryocyte–erythrocyte lineages, respectively. FL counterparts of adult CMPs and CLPs show incomplete lineage restriction to each respective pathway, with FL CLPs showing minor macrophage differentiation capacity and FL CMPs showing minor B-cell potential (dashed lines). Although denoted here, ST HSCs have not been formally identified in murine FL.