Involvement of the MHC class II presentation pathway in the production of IFN-γ by Tax⁺ PBMCs.

(A) Inhibiting effect of an anti-MHC class II mAb on the production of IFN-γ by SK/SD-specific CD4⁺ T lymphocytes. PBMCs were isolated from an uninfected individual, cultivated in vitro for 12 hours with SK/SD, and then harvested. ■ indicates control; ▪, SK/SD. (B) Effect of the anti-MHC class II mAb on the production of IFN-γ by Tax⁺ PBMCs. Cells were isolated from one AC (HT) of the virus and one HAM/TSP patient (TAF) and harvested after 12 hours of cultivation in vitro. ▪ indicates TAF; ■, HT.