Morphology of AV-binding sickle cells.

Bright-field (panels A, B) and epi-fluorescence (panels C, D) micrographs of the same RBCs from a high-density (1.13 g/mL or greater) (panels A, C) or low-density (less than 1.08 g/mL) (panels B, D) sickle cell population. ISCs are defined as cells that are elongated with length 2 or more × width.