Fig. 8.
Ascorbic acid depletes intracellular GSH in mononuclear cells from patients with multiple myeloma.
Mononuclear cells were isolated from BM aspirates as described in “Materials and methods.” Cells (4 × 106) were incubated in the absence (■) or the presence of AA (100 μM; ▪) for 48 hours. GSH levels were determined as described in “Materials and methods” and are presented as the average of 2 patient samples. *Means of the AA-treated cells are lower than of the control cells (P < .005).
