CMV-specific CD8⁺ T cells in renal transplant recipients contain granzyme B.

Dot plots of NLVPMVATV–HLA-A2.1 tetramer-APC fluorescence (“tetramer,” x-axis, arbitrary units, log scale) versus granzyme B–PE fluorescence (y-axis, arbitrary units, log scale) within gated CD8^bright T cells, in a healthy control individual (A) and an immunosuppressed renal transplant recipient (B). Subjects were matched for their CD27⁻CD45RA⁺ phenotype of CMV-specific CD8⁺ T cells.