Fig. 2.
Monitoring EBV load after matched unrelated SCT.
A 16-year-old EBV-seropositive male with a Philadelphia chromosome–positive (Ph+) ALL in first complete remission received a TCD matched unrelated donor graft from an EBV-seropositive donor. Multiple EBV reactivations were observed; however, no EBV-LPD ensued. Frequent examination of bone marrow for the presence of monoclonal B cells and whole-body CT to detect lymphadenopathy were negative at various time points (*). At day 211, DLI (1.0 × 105 CD3+ T cells/kg) was administered because of molecular relapse of his Ph+ ALL. Currently, the patient is free of disease and well at day 800 after SCT. CyA indicates cyclosporin A.
