Inhibition of NF-κB augments TRAIL sensitivity or reverses TRAIL resistance of MM cells.

MTT colorimetric assays indicate that pretreatment with the NF-κB inhibitory peptide SN50 enhances TRAIL (50 ng/mL)-induced cell death in TRAIL-sensitive MM-1S and RPMI-8226/S cells (A,B) and overcomes the TRAIL resistance of ARH-77 and IM-9 cells (C and D, respectively).