Fig. 4.
Transmission electron micrographs of a carotid artery from a β3+/+ and a β3−/− mouse exposed to FeCl3 demonstrate platelet masses in the β3+/+ mouse and a platelet monolayer in the β3−/− mouse.

Transmission electron micrographs of a carotid artery from a β3+/+ and a β3−/− mouse exposed to FeCl3 demonstrate platelet masses in the β3+/+ mouse and a platelet monolayer in the β3−/− mouse.

The carotid artery of the β3+/+ mouse (A-B) was fixed approximately 7 minutes after the application of FeCl3, whereas the artery in the β3−/− mouse (C-F) was fixed after 30 minutes. Dark-staining FeCl3 accumulated along the internal elastic lamina and, in the wild-type artery, within the thrombus. The vessel in the wild-type mouse was occluded by thrombus composed of platelets, fibrin, and erythrocytes (A-B). Primarily a single layer of platelets adhered to FeCl3-treated vessel wall of the in β3−/− mouse (C-D); fibrin and residual erythrocytes were also present. In addition to attaching directly to the damaged wall, platelets accumulated in areas rich in fibrin along the β3−/− artery (E). Along the damaged vessel in β3−/− mouse, adherent platelets recruited leukocytes, and additional platelets attached to the luminal surfaces of the leukocytes (F).

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