Fig. 4.
Fig. 4. Effect of iron loading on H and L ferritin accumulation in liver, spleen, and heart from. / Fth+/+ andFth+/− mice. ThreeFth+/− mice and 3 control littermates received 3 subcutaneous injections of iron dextran (total iron, 30 mg) at 5-day intervals. Mice were killed 5 days after the final injection, together with 3 noninjected animals of each genotype. Both H-type and L-type ferritins were assayed in liver (), spleen (▩), and heart (▪) by means of subunit-specific ELISA. Results are expressed as micrograms of recombinant mouse L or recombinant mouse H ferritin per gram of wet weight and are the mean ± SD of 3 mice. Iron contents for the same organs are shown in Table 1. P values for Fth+/+(iron) vs Fth+/− (iron): P = .006 (liver); P = .0006 (spleen);P = .001 (heart).

Effect of iron loading on H and L ferritin accumulation in liver, spleen, and heart from

Fth+/+ andFth+/− mice. ThreeFth+/− mice and 3 control littermates received 3 subcutaneous injections of iron dextran (total iron, 30 mg) at 5-day intervals. Mice were killed 5 days after the final injection, together with 3 noninjected animals of each genotype. Both H-type and L-type ferritins were assayed in liver (), spleen (▩), and heart (▪) by means of subunit-specific ELISA. Results are expressed as micrograms of recombinant mouse L or recombinant mouse H ferritin per gram of wet weight and are the mean ± SD of 3 mice. Iron contents for the same organs are shown in Table 1. P values for Fth+/+(iron) vs Fth+/− (iron): P = .006 (liver); P = .0006 (spleen);P = .001 (heart).

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