Tissue L ferritin accumulation with age in

Fth^+/+ andFth^+/− mice.Fth^+/− mice (■) and their control littermates (▪) were killed at different times after birth and up to 45 weeks. Liver, spleen, and heart were excised, and L ferritin contents were measured by ELISA with the use of polyclonal subunit-specific anti–mouse ferritin antibodies. The results are expressed as micrograms of recombinant mouse L subunit per gram of wet tissue. The linear regression is shown for both genotypes.