Fig. 2.
Fig. 2. Effect of anti-P1 Fab preincubation. / Anti-P1 Fab preincubation prevents phagocyte accumulation on surfaces of PET disks coated with human fibrinogen (200 μg/mL) and albumin (1000 μg/mL) after 16 hours of implantation in Swiss Webster mice. Vertical lines denote ± 1 SD (n = 5 in all cases). (**Significance vs fibrinogen-coated implants isP < .01.) Estimated numbers of Mφs (cells per square centimeter): 355 000 ± 128 000 on fibrinogen-coated disks; 39 100 ± 8200 on P1 antibody-blocked fibrinogen-coated disks; and 62 700 ± 26 400 on albumin-coated disks. Estimated numbers of PMNs (cells per square centimeter): 47 400 ± 3500 on fibrinogen-coated disks; 27 400 ± 3500 on P1 antibody-blocked fibrinogen-coated disks; and 9600 ± 9100 on albumin-coated disks.

Effect of anti-P1 Fab preincubation.

Anti-P1 Fab preincubation prevents phagocyte accumulation on surfaces of PET disks coated with human fibrinogen (200 μg/mL) and albumin (1000 μg/mL) after 16 hours of implantation in Swiss Webster mice. Vertical lines denote ± 1 SD (n = 5 in all cases). (**Significance vs fibrinogen-coated implants isP < .01.) Estimated numbers of Mφs (cells per square centimeter): 355 000 ± 128 000 on fibrinogen-coated disks; 39 100 ± 8200 on P1 antibody-blocked fibrinogen-coated disks; and 62 700 ± 26 400 on albumin-coated disks. Estimated numbers of PMNs (cells per square centimeter): 47 400 ± 3500 on fibrinogen-coated disks; 27 400 ± 3500 on P1 antibody-blocked fibrinogen-coated disks; and 9600 ± 9100 on albumin-coated disks.

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