American Society of Hematology

Fig. 5.

$Fig. 5. E-selectin–mediated rolling in venules with different wall shear rates. / Rolling flux fraction (mean ± SEM) in cremaster muscle venules of TNFα-pretreated core 2−/− mice (▪) and littermate control mice (░) treated with blocking mAbs against P- and L-selectin. Data for low (less than 300 s−1), normal (300 to 1000 s−1), and high (greater than 1000 s−1) wall shear rates. Results from 24 control venules and 43 core 2−/− venules. * indicates significant differences (P < .05) between core 2−/− mice and control mice.$

E-selectin–mediated rolling in venules with different wall shear rates.

Rolling flux fraction (mean ± SEM) in cremaster muscle venules of TNFα-pretreated core 2^−/− mice (▪) and littermate control mice (░) treated with blocking mAbs against P- and L-selectin. Data for low (less than 300 s⁻¹), normal (300 to 1000 s⁻¹), and high (greater than 1000 s⁻¹) wall shear rates. Results from 24 control venules and 43 core 2^−/− venules. * indicates significant differences (P < .05) between core 2^−/− mice and control mice.

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