Effect of rhIFN-α on BFU-E and CFU-E colonies.

The effect of rhIFN-α on the number of BFU-E (panels A, B) and CFU-E (panels C, D) in the bone marrow (panels A, C) and spleen (panels B, D) of C57BL/6 mice, 14 days after inoculation with P yoelii 265 BY. Control and IFN-α–treated mice, infected or uninfected, were injected IP daily with 0.1% BSA (vehicle) or rhIFN-α (5 × 10⁴ U). CFU-E colonies were scored on day 3 and BFU-E colonies on day 8 after plating. Bone marrow CFU-E and BFU-E are expressed as the number of colonies per femur. Results are presented as mean numbers of colonies ± SE for duplicate cultures from 2 to 4 mice.