Intratumoral injection with MV-Ed or MVlacZ into both DoHH2 and Raji tumors results in significant retardation or regression of tumor growth as compared with controls.

(A-C) Percentage change in tumor volumes after injection with MV (●) or UV-inactivated MV (■) and in noninjected controls (○). The day of injection was designated day 0. The x-axis represents time after intratumoral injection; the y-axis represents tumor volume relative to size at initial MV injection. The 10 days on which MV injections were given are indicated by the brackets with arrows. Panel A shows DoHH2 tumors injected with a total dose of 10⁶ pfu MVlacZ. Panel B shows Raji tumors injected with a total dose of 10⁶ pfu MV-Ed. Panel C shows Raji tumors injected with a total dose of 10⁷ pfu MV-Ed. (D) A comparison between small (< 0.4 cm³) and large (> 0.4 cm³) Raji in their response to MV therapy. All MV-treated Raji tumors, regardless of virus dose, were categorized as large or small (greater or smaller than the mean). The x-axis represents time after intratumoral injection; the y-axis represents tumor size. Tumors that were small at the time of injection (▪) responded significantly better to MV therapy than those that were large at the time of injection (○).