DoHH2 and Raji lymphoma cell lines express CD46 and are lytically infected by MV-Ed and MVlacZ.

(A) Quantification of CD46 expression by fluorescence-activated cell sorter analysis by means of an anti-CD46 antibody and a secondary antibody conjugated to FITC. The shaded histograms represent cells incubated with isotype controls; the line histograms represent the fluorescence intensity of cells after incubation with anti-CD46 antibody. (B) Infection of DoHH2 and Raji cells in suspension culture with MVlacZ. The circles represent the titer on Raji cells; the diamonds represent the titer on DoHH2 cells. (C) Infection of Raji cells by MV-Ed results in a characteristic cytopathic effect, with the formation of multinucleated cells in suspension culture. Noninfected Raji cells are shown in comparison with MV-Ed–infected cells 4 days after infection.