Progressive normalization of hematologic and histologic parameters in chimeric mice with increased normal myeloid chimerism and decreased fractions of sickle Hb.

For percent normal myeloid chimerism, the percentage of normal myeloid chimerism, as measured by dual color flow cytometry of peripheral blood, is plotted along the x-axis with the following outcomes along the y-axis: (A) % normal Hb (HPLC), (C) Hb concentration, (E), pathology score, and (G) blood smear score. For percent HbS (HPLC), the percentage of HbS is plotted along the x-axes with the following outcomes measures along the y-axes: (B) spleen weight, (D) hemoglobin concentration, (F) pathology score, and (H) blood smear score. Correlation coefficients (r) are shown for each of the data sets.