Healing pattern of excisional wounds of control and Fib^−/− mice.

(A-F) Representational views of the gross appearance of excision wounds after 4 days (A and B), 8 days (C and D), and 21 days (E and F) in control (A, C, and E) and Fib^−/− (B, D, and F) mice. Note the open wounds in the Fib^−/− mice in B and D. Microscopic appearance of day 8 excisional wounds of control mice (G) and Fib^−/− mice (H). Note the presence of a prominent sinus or fissure that is bordered by exuberant granulation tissue and covered by epithelium typical of that encountered in Fib^−/− mice (H).