Immunohistochemical analysis of fibrin- (ogen), fibronectin, and procollagen I in wounds of control and Fib^−/− mice.

Fibrin(ogen) immunodetection (brown reaction product) in the wound beds of control (A) but not in Fib^−/− (B) mice on day 4. Note that the epithelium and the granulation tissue of the wounds contain abundant fibronectin (brown reaction product) in both control (C) and Fib^−/− (D) mice. Procollagen I accumulation (pink reaction product) was more prominent in Fib^−/− mice (F) than in control mice (E). Original magnification, 100×.