Fig. 1.
IgG antibody in serum from patient 1.
Serum from patient 1 contained an IgG antibody that recognized normal platelets in the presence of naproxen glucuronide. Antibody binding was not promoted by naproxen or by urine from a normal individual taking naproxen. However, positive reactions were obtained with drug metabolites isolated from the same urine (“urinary metabolites”) and with purified naproxen glucuronide. No reaction was obtained with 6-0-desmethyl naproxen, another metabolite of naproxen. Mean fluorescence intensity values are shown in parentheses.
