Clinical signs of GVD in recipients of B6-cdd CD4 T cells.

Recipients of B6-cdd CD4 T cells exhibited clinical signs of GVHD (weight loss, diarrhea, fur texture, posture, and alopecia). Clinical changes (maximum score, 10) associated with GVHD were assessed by means of a scoring system described in “Materials and methods.” Recipients of 5 × 10⁶ B6-cdd CD4⁺ T cells exhibited a clinical score of 8 within 21 days of BMT (data not shown). ▪, 2.5 × 10⁶ B6; ▾, 0.25 × 10⁶ B6; ■, 2.5 × 10⁶ B6-cdd; ▿, 0.25 × 10⁶B6-cdd donor CD4⁺ T cells.