Fig. 9.
![Fig. 9. Model depicting the dual regulation by MLC kinase and myosin phosphatase of myosin phosphorylation in platelet secretion. / [Ca2+]i indicates intracellular Ca++ concentration; CPI- P○, phosphorylated CPI; DG, diacylglycerol; Ins(1,4,5)P3, inositol 1,4,5-triphosphate; GF109203X, inhibitor of PKC; MBS- P○, phosphorylated MBS at Thr696; MLC20- P○, phosphorylated MLC20 at Ser19; PKN, protein kinase N; PLC, phospholipase C; GEF, Rho-specific guanine nucleotide exchange factor; Y-27632, inhibitor of Rho-kinase.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/12/10.1182_blood.v97.12.3798/6/h81211168009.jpeg?Expires=1724238136&Signature=knZP4VXPJiMzrudDtX9JGHATphwr0UkAErAwIP~ipr~tRlGYqzZU~vpyZREh5yhbTSje-ME9WGtcoUpjUyeQJcb4W8vf0fj4rtsCxgih3t3iDr8mDK6bjZikszFPD5F2ReI4ZmaLEYqm1kk-~8~bsb6Ek7SvMFSBgnZpJcdYcObLiAVCr81H2yZMsJamq-o8PGbS2aBWcbcoYasq8Z58VjsY8a8W-wpSOLCBfNYn~1mGtPHoTz2HDJl7ZGJvICTaOr4xJyw6XVbvFLbtg9pSpQuboXe7ckAfsi6-HFrGa2HgXU7106WaCCL7wS5UOwRjKtnZqGcv7hvj97EX2zMFcQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Model depicting the dual regulation by MLC kinase and myosin phosphatase of myosin phosphorylation in platelet secretion.
[Ca2+]i indicates intracellular Ca++ concentration; CPI- P○, phosphorylated CPI; DG, diacylglycerol; Ins(1,4,5)P3, inositol 1,4,5-triphosphate; GF109203X, inhibitor of PKC; MBS- P○, phosphorylated MBS at Thr696; MLC20- P○, phosphorylated MLC20 at Ser19; PKN, protein kinase N; PLC, phospholipase C; GEF, Rho-specific guanine nucleotide exchange factor; Y-27632, inhibitor of Rho-kinase.
