Fig. 7.
Position of the amino acid substitution in the γ-chain of fibrinogen Milano XII.
The mutation site (γ G165R) is situated in a loop formed by an intrachain disulfide bridge between γ 153 C and γ 182 C. The figure shows the γ-chain of fibrinogen and is adapted from the crystal structure (IFZB from the Brookhaven Data Bank) of fragment D reported by Spraggon et al.1
