Histopathologic and flow-cytometric analysis of mice transplanted with bone marrow transduced by H4/PDGFβR retrovirus.

Mice transplanted with bone marrow transduced with H4/PDGFβRretrovirus develop a lethal hematopoietic malignancy after a latency of approximately 150 days. The disease is characterized by proliferation of immature T cells (CD4^+/+ and CD8^+/+ cells), with infiltration of spleen (A, high-power view), bone marrow (B, low-power view), and lymph node (C, high-power view). Flow cytometry of the lymph node (D) demonstrates a predominant CD4^+/+CD8^+/+ T-cell population.