Plasmin triggers concentration-dependent expression of IL-1α, IL-1β, TNF-α, and TF mRNA in human monocytes.

Monocytes were incubated with the indicated concentrations of LPS-free plasmin for 4 hours. Expression of mRNA was measured by semiquantitative RT-PCR. HLA(B) was used for normalization. Results are the mean ± SEM of 5 independent experiments. *P < .05 and **P < .01. versus unstimulated controls.