Fig. 2.
JAQ1 potentiates the P2Y12 component of platelet aggregation induced by ADP.
(A) Washed platelets were activated with 5 μM ADP in the presence or absence of JAQ1 (10 μg/mL). Tritiated serotonin secretion is indicated in brackets. (B) Washed platelets were incubated with JAQ1 (10 μg/mL), followed by the selective P2Y1 receptor antagonist MRS2179 (100 μM) or the selective P2Y12receptor antagonist AR-C69931X (10 μM), and then activated with ADP (5 μM). Tritiated serotonin secretion is indicated in brackets.
