Percentage survival curve of IL-1Ra and GC chimeric mice after a second challenge with the anti-GBM antibody.

The anti-GBM antibody was repeatedly injected into chimeric mice 28 days after the primary injection, and survivors were counted (10 per group). As a control, the percentage survival curve of age-matched wild-type female mice is also shown. GC chimera (n = 10), ■; IL-1Ra chimera (n = 10), ▪; wild-type female mice (n = 10), ▴.