Effect of bone marrow reconstitution with IL-1Ra on urine albumin secretion after nephritis induction.

An anti-GBM antibody was infused into IL-1Ra and GC chimera, and urine albumin was measured by single radial immunodiffusion. As a control, urine albumin secretion from wild-type female mice administered with anti-GBM antibody was also measured (dotted line). Data are presented as means ± SE. Asterisks indicate significant differences (P < .05) between the 2 groups. GC chimera (n = 10), ■; IL-1Ra chimera (n = 10), ▪.