Schematic presentation of the 3′- end of the intron 27 and 5′- end of the exon 28 of the

VWF gene, showing the base pair differences detected in propositus investigated in this study and other reported cases of gene conversion between VWF and pseudogene.Selected nucleotides and their numbers for the wild-type VWFgene are shown together with the corresponding bases of the pseudogene at these positions. Nucleotides in bold in the third line (from the top) shows those that match with bases in the pseudogene in our own and the other reported patients.15-17 Below each changed nucleotide, the resulting amino acid substitution is shown, and finally at the bottom the predicted maximal and minimal length of the putative converted sequences and the reported VWD phenotype are shown. The location and the nucleotides of the chi-like sequence is indicated.19