Schematic representation of the enzymatic pathways involved in the release of su-PAR from activated hMVECs in the absence or presence of MMP inhibitors.

(1) Indicates cleavage of D1D2D3 by phospholipase D11; (2) indicates cleavage of D1 from the u-PAR by u-PA/plasmin12 13; and (3) indicates cleavage of D1 from the u-PAR by MMP-12 activity (this paper).