hMIP-1α induces osteoclasts that resorb dentin.

Human CFU-GM–derived cells were cultured in the presence of dentin slices in the presence or absence of MIP-1α (200 pg/mL). At the end of the cultures, the dentin slices were stained for tartrate-resistant acid phosphatase activity and then photographed. Similar results were seen in 2 independent experiments (original magnification × 100).