Fig. 1.
MIP-1α induces osteoclast formation in human marrow cultures.
Long-term human marrow cultures were established and treated with varying concentrations of recombinant hMIP-1α. Controls for these experiments were cultures treated with 1,25-(OH)2D3 (10−8 M). MIP-1α at concentrations of 5 to 200 pg/mL significantly increased osteoclast formation in these cultures. Results represent the mean ± SEM for quadruplicate determinations for a typical experiment. Similar results were seen in 3 independent experiments. *P < .05 compared to culture lacking MIP-1α.
