CD44-dependent IL-6 production requires protein transcription and tyrosine kinase activity.

Freshly purified PMNs isolated from a buffy coat from a normal donor were stimulated as indicated in the presence (closed bars) or absence (open bars) of metabolic inhibitors: actinomycin D (A), genistein (B), and staurosporine (C). The figure shows 1 of 3 experiments performed with similar results.