Induction of GVHD by CD8⁺ NKT cells across histocompatibility barriers.

Donor (C57BL/6) (H-2^b) splenocytes or expanded CD8⁺ NKT cells at the indicated doses were injected into lethally irradiated Balb/c (H-2^d) recipients. Mean body weight (top panel) and survival (bottom panel) are presented. ▵ indicates XRT; , splenocytes; ■, BM; ✙, NK − T cells 20 × 10⁶; ⋄, NK − T cells 10 × 10⁶; and ▿, NK − T cells 5 × 10⁶.