Cytotoxicity of unprimed and primed effectors against unmanipulated autologous AML blasts.

Primed effectors were autologous T cells cultured with leukemic DCs and IL-2 for 14 days. Unprimed effectors were autologous T cells cultured with IL-2 only. Results represent cytotoxicity against autologous blast cells at an effector-to-target ratio of 50:1. Experiments in which primed effectors produced more than 1.5-fold greater killing of autologous blast cells than unprimed effectors were considered positive. indicates unprimed; ▩, primed.