Fig. 2.
![Fig. 2. fVIII-Specific T-cell proliferative response is suppressed after blocking CD40-CD40L interaction in vivo. / T cells and peritoneal macrophages from 2 mice injected with fVIII (■) or 2 mice treated with anti-CD40L plus fVIII (●) were harvested at the end of the treatment and cocultured with increasing concentrations of fVIII. After 4 days, cells were pulsed with 1 μCi [3H]-thymidine, and incorporation of radioactivity was measured. Results are expressed as the mean of counts per minute (CPM) ± 1 SD of triplicate wells.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/9/10.1182_blood.v97.9.2750/6/h80911007002.jpeg?Expires=1724137839&Signature=bWRJ2~SP~dRgCXlAhQlRBI1-YPYvtaRkHKdKuNhBiWm6uU1vNLzdwmVM8~-nyGRHGhM8OX~VBGR87QgSTn4pxha5GJS0cWmQnqiDJr4Mw9wSgRLud2glnzizw9tStjGUlTOdZKGQlXEOf0nBc~Tn-YsjJcqC6fVMdQ4pgnKFv5RKC0Vemz5U7y8kI-34W8lVu-VA3zzfCYi2khUjCYGDwA2QVhHOK0Yn9cgfxmFatdg0yxoItYIvjsZGbUapAClQIcmkYSOyQrjE-RDvK5Z60lxeDJKQzAv35JI73p-bTZHlmeoULsLh8sc-s8u-73vJqRaXYUYImDjUC9RPtQnyNw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
fVIII-Specific T-cell proliferative response is suppressed after blocking CD40-CD40L interaction in vivo.
T cells and peritoneal macrophages from 2 mice injected with fVIII (■) or 2 mice treated with anti-CD40L plus fVIII (●) were harvested at the end of the treatment and cocultured with increasing concentrations of fVIII. After 4 days, cells were pulsed with 1 μCi [3H]-thymidine, and incorporation of radioactivity was measured. Results are expressed as the mean of counts per minute (CPM) ± 1 SD of triplicate wells.
