Growth and replication of CFU-GM.

(A) Growth rates of CFU-GM colonies grown from normal human bone marrow CD34⁺ cells transduced with wild-type CDK4 (WT-CDK4) or empty vector (pBN). n = number of colonies analyzed in each group. (B) Replicative capacity of CFU-GM, as reflected by the AUC, grown from WT-CDK4–transduced or control-transduced CD34⁺ normal human marrow cells. Samples from 3 donors were analyzed.