Induction of dimerization by a CID.

A chimeric growth switch consisting of receptor sequences and a dimerization domain is activated on addition of a CID. The CID enforces dimerization by binding 2 dimerization domains on 2 neighboring molecules with a 1:2 stoichiometry. Dimerization causes signaling from the receptor sequences. The principle is the same for the coumermycin-GyrB system and the FK1012-FKBP system. The molecule shown also carries a myristylation domain derived from c-src for targeting to the inner cell membrane.