Fig. 6.
Fig. 6. Whole blood coagulation and Integrilin. / Comparison of whole blood coagulation in the absence (▪) and presence (●) of 5 μM Integrilin. Coagulation was initiated in whole blood by 25 pM relipidated TF as described in “Materials and methods.” Panel A represents thrombin (TAT) generation, panel B fibrin (FPA) formation, and panel C platelet activation (osteonectin [ON] release). Arrow “a” indicates clotting times for the control experiment, arrow “b” for the Integrilin experiment.

Whole blood coagulation and Integrilin.

Comparison of whole blood coagulation in the absence (▪) and presence (●) of 5 μM Integrilin. Coagulation was initiated in whole blood by 25 pM relipidated TF as described in “Materials and methods.” Panel A represents thrombin (TAT) generation, panel B fibrin (FPA) formation, and panel C platelet activation (osteonectin [ON] release). Arrow “a” indicates clotting times for the control experiment, arrow “b” for the Integrilin experiment.

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