Summary of longitudinal repertoire studies in 8 patients and 2 controls.

Each black bar represents the average CD8 repertoire perturbation calculated from Immunoscope data on 9 BV families, at a given time point. CD4 absolute counts (gray diamonds) and HIV viremia (black squares) are shown on top of repertoire data. Patients T8, T17, T18, and T20 had successful therapy, as defined by an increase in CD4 absolute counts and a decrease of HIV viral load (remaining below detection level at M12). For patients with successful therapy, there was a decrease in average CD8 repertoire perturbation (black bars). Note for patient T19 the transient decrease in perturbation that parallels an initial efficient control of HIV replication. Data for seronegative controls C4 and C5 are also presented.