Longitudinal tracking of clonal expansions.

For patients with successful therapy (responders), there was a significant decrease in the number of overrepresented CDR3 peak sizes. Clonal expansions that were stable over the indicated time of follow-up are black. New clones (those not found dominant in previous sample) are gray or white. Note the repertoire shift for patients T18 and T19. A dedicated algorithm was used to track overrepresented areas (compared to control profiles) among all Immunoscope profiles from the study.