Anti–MMP-9 neutralization of SB-251353–induced hematopoietic progenitor cell mobilization in the mouse.

We injected 3 mg/kg neutralizing antihuman MMP-9 antibody (clone 6-6B) IV 2 hours prior to SQ administration of 2.5 mg/kg SB-251353. Isotype control antibody does not inhibit SB-251353–induced CFU-GM mobilization (data not shown). Each time point represents data from 3-4 mice. *P < .01 increase in CFU-GM/mL blood compared with PBS control and antibody-pretreated mice.