Comparison of the effects of STI571 on cellular proliferation and viability in Ba/F3 cells expressing BCR/ABL, TEL/ARG, TEL/ABL, TEL/PDGFR, or TEL/JAK2.

(A) Growth of cells cultured in the presence of increasing concentrations of STI571 (0.01-5 μM) for 24 hours. (B) Growth of cells cultured in the presence of increasing concentrations of STI571 (0.01-5 μM) for 48 hours. (C) Growth of cells cultured in the presence of increasing concentrations of STI571 (0.01-5 μM) for 72 hours. For all cell lines, values obtained for the 24-hour time points were calculated as the average of 3 independent experiments, shown as percentage untreated (control) cells. Values obtained for the 48- and 72-hour time points, respectively, were calculated as the average of 2 independent experiments, shown as percentage untreated (control) cells. Each cell line is represented by a different symbol, as shown in the figure legends.