Fig. 3.
![Fig. 3. Synergistic inhibitory effects of STI571 and AG490 on BCR-ABL-expressing cell lines. / (A) Experiments using the cell line FDrv210H (18-hour incubation in inhibitors), titrating STI571 in a constant concentration of AG490. In panels A and B, solid (+IL-3) and open (−IL-3) symbols identify curves for varying concentrations of AG490 alone (●,○) STI571 alone (▴,▵), and serial dilutions of STI571 in a constant concentration AG490 [5 μM] (♦,⋄). (B) Experiment using the cell line 32Dp210 (18-hour incubation in inhibitors), titrating STI571 in a constant concentration of AG490. (C) For a constant STI571 concentration (0 or 0.01 μM), AG490 was added at the concentrations shown (MO7p210 cell line; 18-hour incubation in inhibitors without GM-CSF).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/97/7/10.1182_blood.v97.7.2008/6/h80710843003.jpeg?Expires=1724829932&Signature=WmU78jCOUZIEb0E1EnevcLKOEob3QRDeaSX1vqyhemjiKkPDlv87bifP7yr4xvccto1OTFDP1UaxqA4ETvkdPqYrj5v6b7OTxv7kBKHiWjhdXWfRaGdzlAjNxLnze-SPegtm2H~UjYKr4YgZnS7D~blurL0jEL06ShpQBQDk9hPF0ip~JUM7pn51F1m6RUL9yvdPT2RSj3qoeRFVMJet-s1N6I7UOP62-MmKIEtfnur8wyfv09e5RJdJ9oTV1MypSDJVnL~-lgdlGLdD9PNWzttJHj96-Ku6wmjBh4GIqz5OUlSIg4ts~gS57T3IZpPU0BrHLDTkGLz3Pylp2OeMzQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Synergistic inhibitory effects of STI571 and AG490 on BCR-ABL-expressing cell lines.
(A) Experiments using the cell line FDrv210H (18-hour incubation in inhibitors), titrating STI571 in a constant concentration of AG490. In panels A and B, solid (+IL-3) and open (−IL-3) symbols identify curves for varying concentrations of AG490 alone (●,○) STI571 alone (▴,▵), and serial dilutions of STI571 in a constant concentration AG490 [5 μM] (♦,⋄). (B) Experiment using the cell line 32Dp210 (18-hour incubation in inhibitors), titrating STI571 in a constant concentration of AG490. (C) For a constant STI571 concentration (0 or 0.01 μM), AG490 was added at the concentrations shown (MO7p210 cell line; 18-hour incubation in inhibitors without GM-CSF).
