Cytotoxicity of CTLs against DCs.

(A) Cytotoxicity of CTL lines generated from patients 1 (●) and 2 (○) against DCs pulsed with the autologous Id at different effector–target (E:T) ratios. (B) Comparison of the cytotoxicity of CTLs from patients 1 (▪) and 2 (■) against DCs pulsed with the autologous Id (Auto-Id-DCs), the allogeneic Id protein from the other patient (Allo-Id-DCs), an isotype-matched Id protein (Iso-Id-DCs), or unpulsed DCs (DCs only). The E:T ratio was 20:1. (C) Inhibition by antibodies against MHC class I and class II or an isotypic control IgG on the cytotoxicity of CTLs from patients 1 (▪) and 2 (■). Data are expressed as the mean ± SEM of 4 independent experiments.